‘Striking findings’ from OSU prof’s study on fat and depression

Jeff Volek

Excerpt

Depression among college students has reached crisis levels. Nearly half of U.S. college students report symptoms of depression, and about 15% say they’ve considered suicide — a fifteen-year high. One-fifth take prescription antidepressants, and more than one-third receive mental-health counseling. 

As a professor at The Ohio State University, I’ve seen firsthand the toll this crisis takes on my students. But as a scientist studying low-carbohydrate diets for over two decades, I’ve also seen something else: individuals following these diets often experience unexpected improvements in mental health.

That apparent connection and the understanding that some of the documented benefits of a ketogenic diet overlap with the pathophysiology of depression sparked my scientific curiosity — and a first-of-its-kind pilot study.

What we learned about fat and mental health

My colleagues and I recently set out to examine whether a whole-food, well-formulated ketogenic diet — high in healthy fats, moderate in protein and very low in carbohydrates — could support students being treated for major depressive disorder. 

The results were striking. 

Over 10 to 12 weeks, participants followed a supervised ketogenic diet while continuing their usual counseling or medication. Of the 24 students who enrolled, 16 completed the program and maintained a state of nutritional ketosis — meaning their bodies had shifted away from relying on carbohydrates for fuel to utilizing primarily fat.

By the end of the study, symptoms of depression had fallen by about 70% on two widely used clinical scales, while self-reported well-being nearly tripled.

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